The SPDL1 Antibody from MyBioSource.com is a Rabbit Polyclonal antibody to SPDL1. This antibody recognizes Human, and Mouse antigen. The SPDL1 Antibody has been validated for the following applications: Western Blot.
Description
Required for the localization of dynein and dynactin to the mitotic kintochore. Dynein is believed to control the initial lateral interaction between the kinetochore and spindle microtubules and to facilitate the subsequent formation of end-on kinetochore-microtubule attachments mediated by the NDC80 complex. Also required for correct spindle orientation. Does not appear to be required for the removal of spindle assembly checkpoint (SAC) proteins from the kinetochore upon bipolar spindle attachment. Interacts with KNTC1 and ZW10. These interactions appear weak and may be transient or indirect